Resistance and Progression Mechanisms in Prostate Cancer

Alvaro Aytés Meneses

PRINCIPAL INVESTIGATOR
  • Jose Francisco Suarez Novo
  • Maria Pané Foix
CLINICAL RESEARCHERS
  • Natalia Picola Brau
POSTDOCTORAL RESEARCHERS
  • Rana El Bizri
  • Lidia Franco Luzon
  • Ana Sofia Semiao  Da Rocha
PREDOCTORAL RESEARCHERS
  • Sonia Farran Matas
  • Adrian Martinez Tébar
SCIENTIFIC SUPPORT
  • Xieng Chen Wang
Cancer
Oncobell

Scientific production

9

PAPERS

Impact factor: 107,638

4 PUBLICATIONS IN FIRST DECILE

7 PUBLICATIONS IN FIRST QUARTILE

5 PUBLICATIONS IN FIRST QUARTILE

Selected publications

  • de Porras VR, Wang XC, Palomero L, Marin Aguilera M, Sole Blanch C, Indacochea A, Jimenez N, Bystrup S, Bakht M, Conteduca V, Piulats JM, Buisan O, Suarez JF, Pardo JC, Castro E, Olmos D, Beltran H, Mellado B, Martinez Balibrea E, Font A, Aytes A. Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment. Eur Urol. 2021;79(6):722-733. doi:10.1016/j.eururo.2020.10.001. IF:20,10.
  • Ruiz de Porras V, Font A, Aytes A. Chemotherapy in metastatic castration-resistant prostate cancer: Current scenario and future perspectives. Cancer Lett. 2021;523162-169. doi:10.1016/j.canlet.2021.08.033. IF:8,68.
  • Paull EO, Aytes A, Jones SJ, Subramaniam PS, Giorgi FM, Douglass EF, Tagore S, Chu B, Vasciaveo A, Zheng SY, Verhaak R, Abate Shen C, Alvarez MJ, Califano A. A modular master regulator landscape controls cancer transcriptional identity. Cell. 2021;184(2):334-doi:10.1016/j.cell.2020.11.045. IF:41,58.
  • Liu Q, Palomero L, Moore J, Guix I, Espin R, Aytes A, Mao JH, Paulovich AG, Whiteaker JR, Ivey RG, Iliakis G, Luo DX, Chalmers AJ, Murnane J, Pujana MA, Barcellos Hoff MH. Loss of TGF beta signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types. Sci Transl Med. 2021;13(580):doi:10.1126/scitranslmed.abc4465. IF:17,96.
  • Condom M, Climent F, Fernandez D, Colomer D, Lopez Guerra M, Varela M, Carro I, Maluquer C, Mercadal S, Oliveira AC, Pane M, Matias Guiu X, Gonzalez Barca E, Sureda A, Domingo Domenech E. Clonal relationship in multisited mucosa-associated lymphoid tissue lymphomas: a single-centre experience. Br J Haematol. 2021;A(6):1020-1025. doi:10.1111/bjh.16717. IF:7,00.

Research highlights

PROJECTS

9 Competitive projects
3 Non competitive projects
8 Clinical trials

Selected projects

  • USA21005. Dissecting the role of cancer cell chromatin remodeling on the landscape of tumor immune microenvironment. (PC210340). DEPARTMENT OF DEFENSE USA. CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS. IP:AYTES MENESES,ALVARO.
  • 18INT004. Mechanisms ant therapeutic targeting of NSD2 in advanced prostate cancer. (W81XWH1810193). DEPARTMENT OF DEFENSE USA. CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS. 2018-2022. IP:AYTES MENESES,ALVARO.
  • AEC21002. Dissecting EZH2-SWI/SNF antagonism to target cell plasticity in therapy resistant prostate cancer. (LABAE211710AYTE). AECC. 2021-2024. IP:AYTES MENESES,ALVARO.
  • 20FIS003. Therapeutic landscape and predictive biomarkers for DNA damage repair pathway inhibitors in advanced prostate cancer. (PI19/00342). 2020-2022. IP:AYTES MENESES,ALVARO.
  • 16FIS040. CONTRATOS MIGUEL SERVET TIPO I (CONTRATO). 2016-2021. IP:AYTES MENESES,ALVARO.