Innate Immunity and Pathology of the Critical patient

Rafael Mañez Mendiluce

PRINCIPAL INVESTIGATORS
  • Joan Sabater Riera
  • Cristina Costa Valles
CLINICAL RESEARCHERS
  • Juan Carlos Lopez Delgado
  • Francisco Esteve Urbano
  • Marta Huguet Briva
  • Gabriel Jesús Moreno Gonzalez
  • Luisa Corral Ansa
  • Jose Luis Perez Fernandez
COLLABORATORS
  • Salvador Ventura Pedret
PREDOCTORAL RESEARCHERS (R1)
  • Ricard Soley Corderas
  • Sara Olivera Ardid
  • Victor Daniel Gumucio Sanguino
SCIENTIFIC SUPPORT
  • Leila González Barrera
SCIENTIFIC SUPPORT
  • Maria Beatriz Carretero Yarza
Translational Medicine
Infectious disease and transplantation

Scientific production

20

PAPERS

PUBLISHED WORKS

Impact factor: 141,188

4 PUBLICATIONS IN FIRST DECILE

6 PUBLICATIONS IN FIRST QUARTILE

Selected publications

  • Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort, Tsang JS, Goldbach-Mansky R, Kisand K, Lionakis MS, Puel A, Zhang SY, Holland SM, Gorochov G, Jouanguy E, Rice CM, Cobat A, Notarangelo LD, Abel L, Su HC, Casanova JL.. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. SCIENCE. 10.1126/science.abd4585
  • Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schlüter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D’Angio’ M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Çölkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela ŞN, Rodríguez-Gallego C, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort; NIAID-USUHS/TAGC COVID Immunity Group, Snow AL, Dalgard CL, Milner JD, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli MJ, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, García-Sastre A, Krammer F, Pujol A, Duffy D, Lifton RP, Zhang SY, Gorochov G, Béziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL.. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. SCIENCE. 10.1126/science.abd4570
  • Nadim, Mitra K.; Forni, Lui C.; Mehta, Ravindra L.; Connor, Michael J., Jr.; Liu, Kathleen D.; Ostermann, Marlies; Rimmele, Thomas; Zarbock, Alexander; Bell, Samira; Bihorac, Azra; Cantaluppi, Vincenzo; Hoste, Eric; Husain-Syed, Faeq; Germain, Michael J.; Goldstein, Stuart L.; Gupta, Shruti; Joannidis, Michael; Kashani, Kianoush; Koyner, Jay L.; Legrand, Matthieu; Lumlertgul, Nuttha; Mohan, Sumit; Pannu, Neesh; Peng, Zhiyong; Perez-Fernandez, Xose L.; Pickkers, Peter; Prowle, John; Reis, Thiago; Srisawat, Nattachai; Tolwani, Ashita; Vijayan, Anitha; Villa, Gianluca; Yang, Li; Ronco, Claudio; Kellum, John A.. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. NATURE REVIEWS NEPHROLOGY. 10.1038/s41581-020-00356-5
  • Madotto F, Rezoagli E, Pham T, Schmidt M, McNicholas B, Protti A, Panwar R, Bellani G, Fan E, van Haren F, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group.. Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study. CRITICAL CARE. 10.1186/s13054-020-2826-6
  • Anguela-Calvet L; Moreno-Gonzalez G; Sbraga F; Gonzalez-Costello J; Tsui S; Oliver-Juan E. Heart Donation From Donors After Controlled Circulatory Death. TRANSPLANTATION. 10.1097/tp.0000000000003545

Research highlights

PROJECTS

5 Ongoing projects
2 Granted project

 

13 Ongoing clinical trials

5 Started clinical trials

INNOVATION

1 Patent

1 license

1 spin-off 

Selected projects

  • Elicitation of protective Immunity against SARS-CoV2 by selective Removal of non-neutralizing Antibodies used by the virus to enhance its infectivity (ICoVRA) (2020 – 2021) PI: MAÑEZ MENDILUCE, RAFAEL. Funder: DEPARTAMENT SALUT (PR).
  • Papel de los anticuerpos naturales anticarbohidrato en el desarrollo de infecciones nosocomiales por gérmenes gram-negativos multiresistentes (2018 – 2020) PI: MAÑEZ MENDILUCE, RAFAEL. Funder: .
  • A randomized, double-blind, placebo controlled, phase 3 study to evaluate the efficacy and safety of QPI-1002 for prevention of major adverse kidney events (MAKE) in subjects at high risk for acute kidney injury (AKI) following cardiac surgery (2018 – 2020) PI: SABATER RIERA, JOAN. Funder ref.: QRK309.
  • A multicenter, randomized, open-label, parallel group pilot study to evaluate safety and efficacy of convalescent methylene blue treated (MBT) plasma from donors recovered from coronavirus disease 2019 (COVID-19) with standard medical Treatment (SMT) versus SMT alone in subjects with COVID-19 requiring admission to the intensive care unit (ICU) (2020 – 2021) PI: MAÑEZ MENDILUCE, RAFAEL. Funder ref.: GC2003.
  • Observational cohort study to characterise the current use of parenteral nutrition and clinical outcomes in adult critically ill patients hospitalised in intensive care units in europe (2020 – 2021) PI: LóPEZ DELGADO, JUAN CARLOS. Funder ref.: NSCR-003-CNI.